Missouri State Bears vs New Mexico State Aggies Prediction, Odds and Picks for Tomorrow, 10/22/25

The Missouri State Bears head out west to face the New Mexico State Aggies in Las Cruces on Wednesday night. After getting absolutely torched at USC in the opener, 73-13, the Bears have stayed the course and pulled things together. They scored nice road wins at Marshall and Middle Tennessee, and are back to .500. However, it won just 22-20 at MTSU last time out, failing to cover as a 2.5-point favorite. The Under has cashed in five straight games since that annihilation at Los Angeles Memorial Coliseum to open the season.

For New Mexico State, like MO State, it is also 3-3. This game is crucial for both teams, in terms of bowl eligibility. Missouri State would get a bid only if enough bowl-eligible teams cannot fill the spots, as it is transitioning to FBS. But, it has a good shot at satisfying bowl-eligibility criteria. The Aggies have been stout at home, winning all three games, including a 37-10 rout of Sam Houston on Oct. 2 in the most recent home contest. It is also 2-0 ATS at home against FBS opponents, while covering the past two. The Over is 3-1 in the past four games, so it’s a rather conflicting trend for totals. We’ll lean into the moneyline for the home side, as the Aggies nearly pulled off the upset at Liberty, and they’re playing really good ball lately.

New Mexico State Moneyline (+100) at time of publishing. Playable to -110.