Nevada Wolf Pack vs Penn State Nittany Lions Prediction, Odds and Picks for Saturday, 08/30/25

Penn State enters the season as one of the favorites to win the national title for good reason. The Nittany Lions are top 10 nationally in returning offensive production, with nearly 76% of its offense back in Happy Valley this year, and they have arguably the best duo of coordinators in the country in Andy Kotelnicki and Jim Knowles – the latter of whom was plucked from Ohio State in the offseason. Knowles is one of the best defensive minds in the sport and has repeatedly improved defenses at multiple programs across the country, so his presence could help Penn State overcome the loss of multiple pieces to the NFL, including Abdul Carter and Kobe King. 

Unlike Penn State, Nevada returns just 35% of its production from last season – one of the bottom 15 marks in the country. In Jeff Choate’s first season as an FBS head coach, the Wolf Pack went 3-10 overall in 2024, losing by double digits in 3 of their last 5 games. Now, they have to replace their quarterback, who also led the team in rushing, 3 offensive line starters, top 3 running backs, and top 2 wide receivers on the road against a Big Ten opponent with national championship aspirations. Can you say mismatch?

James Franklin may struggle to win big games, but the Nittany Lions have been an ATM in games like this. In fact, Penn State is 3-0 ATS over the last 2 years when laying at least 40 points. Expect much of the same here. Penn State in a runaway.

Nevada vs Penn State prediction: Penn State Nittany Lions -44 (-110) available at the time of publishing. Playable at that number or better.

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