North Texas Mean Green vs Charlotte 49ers Prediction, Odds and Picks for Friday, 10/24/25

The North Texas Mean Green bounced back from their first loss of the season, improving to 6-1 with a 55-17 win over UTSA. The Roadrunners never stood a chance, as the Mean Green jumped out to a 17-7 first quarter lead and never looked back. They outgained the Roadrunners 584-329, accumulating 270 of those yards on the ground at 6.1 yards per carry. 

UNT has surpassed 35 points in all but one game, which was a 33-30 overtime win over Western Michigan in Week 2. Meanwhile, Charlotte has yet to surpass 35 points against any FBS opponent. In fact, the 49ers haven’t even surpassed 26 points against FBS competition. Their most recent outing was a 49-14 home loss to Temple in which they trailed 28-7 at halftime, turned the ball over 3 times and passed for only 158 yards. 

There isn’t much history between these teams, as they’ve only met twice. The 49ers took both of those meetings back in 2019 and 2020, but these programs are in very different positions now. With a top-30 ranking in both PPA per play and success rate since Week 4, North Texas has the best offense Charlotte will have seen since its game against South Florida – one the Niners lost 54-26. It could have even been worse if USF didn’t turn the ball over 4 times. 

Charlotte ranks outside the top 100 in most metrics on both sides of the ball, and with UNT sitting at 2-1 in the conference race behind 3 undefeated teams, the Mean Green have absolutely no wiggle room. Look for them to take care of business and win by margin over a rebuilding Charlotte program. 

North Texas vs Charlotte prediction: North Texas Mean Green -26.5 (-110) at the time of publishing. Playable to -27.

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