Notre Dame Fighting Irish vs Stanford Cardinal Prediction, Odds and Picks for Saturday, 11/29/25

Rivals meet at Stanford Stadium on Saturday, as the Notre Dame Fighting Irish battle the Cardinal in the Bay Area. One team is fighting to make it all the way out of an 0-2 hole and into the College Football Playoffs, while the other is simply playing out the string and ready to go home for the holidays.

Notre Dame, of course, is the contender, and it has won nine straight games since losing to fellow playoff hopefuls Miami and Texas A&M. The Fighting Irish not only need to tick off victories, they need style points, too. Last week, Notre Dame flexed a lot of offensive muscle in a 70-7 win against Syracuse, covering as a 37-point spread in the shadows of Touchdown Jesus. That’s three straight covers for the Irish, averaging 52.0 points per game in the three-game span. On the road, Notre Dame has won each of its past three games by an average margin of 26.7 points per game. It has won its past 3 games by an average of 41.3 points per game. On the flip side, Stanford is coming off an impressive 31-10 win in the “Big Game” against Cal last week on The Farm. It has covered back-to-back games, but it has lost back-to-back games to Notre Dame by at least 33 points, including a 49-7 setback last season. Notre Dame is gonna keep its foot on the gas, and score style points at all costs, and Stanford will offer very little resistance in this one.

Notre Dame vs Stanford prediction: Notre Dame -32 (-110) at time of publishing. Playable to -33.5.

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