Ohio State Buckeyes vs Purdue Boilermakers Prediction, Odds and Picks for Saturday, 11/08/25

The Ohio State Buckeyes hit the road for West Lafayette to battle the lowly Purdue Boilermakers. The No. 1-ranked Buckeyes rolled the Penn State Nittany Lions last week, and it has scored 34 or more points in each of the past four games, while going 7-0-1 against the spread (ATS) this season. The defense allowed 14 points in the first two quarters last week against the Nittany Lions, but the D has still allowed just 55 points through eight games, or 6.9 points per game (PPG). Ohio State rolled to a 45-0 win on Nov. 9, 2024 last season in Columbus, covering a 37-point mark, and the Buckeyes are 3-0 ATS in the past two games, covering spreads of 17 or more points. Ohio State has scored 41 or more points in four of the past five tries against Penn State, and the winning team has scored at least 41 points in each of the past five in the series.

For Purdue, it is 2-7 SU/3-5-1 ATS in nine games this season. While the Boilermakers did put up a fight, falling just 21-16 last week at Michigan as a 21-point underdog, the offense continues to struggle to cobble together any points. The defense hasn’t really been trampled in the past four games, but that’s also against Michigan, Rutgers, Northwestern and Minnesota. In three straight games against USC, Notre Dame and Illinois, the Boilermakers allowed 132 total points, or 44.0 PPG, including 99 combined points against the Illini and Irish. QB Julian Sayin, WR Jeremiah Smith and the Buckeyes should roll the Boilermakers.

Ohio State -30 (-110) at time of publishing. Playable to -33.5.