Ohio State Buckeyes vs Washington Huskies Prediction, Odds and Picks for Today, 09/27/25

It’s not often that the top team in the AP Poll hits the road against an unranked opponent and is laying less than double digits, but that’s exactly what we have on Saturday when the Ohio State Buckeyes are in Seattle to take on the Washington Huskies. This is the conference road opener for an Ohio State team that has been on cruise control since its season-opening win over Texas in Week 1. However, it’s reasonable to put that victory under a lot of scrutiny considering what we’ve seen from Texas’ offense since that point, especially since Ohio State was pretty fortunate to win that game by all accounts. In fact, the Buckeyes had a postgame win expectancy of 18% in that contest, as the Longhorns’ turnovers and red zone woes proved to be the difference in Columbus.

Texas was able to move the ball consistently in that game and that’s not exactly a high-powered offense, as we’ve seen in the weeks since. Now, Ohio State makes a cross-country trip for a matchup against a Washington offense that is 9th in success rate, 1st in third- and fourth-down success rate, 1st in quality drive rate and 1st in points per drive. This has been an elite unit, and I’m of the belief that Demond Williams Jr, Jonah Coleman, Denzel Boston and company should be able to generate success against an Ohio State defense that is 74th in EPA per pass and 48th in EPA per rush.

On the other side of the ball, the Buckeyes should certainly hold some edges against this Washington defense, which is coming off a middling showing in the Apple Cup against Washington State. The Huskies have talent on this unit, but Jedd Fisch’s team is still outside the top 50 in quality drive rate, opponent EPA per dropback and third- and fourth-down success rate, while also sitting at 43rd in success rate allowed and 97th in points per drive. However, there are some concerns to be had with Ohio State’s offense, particularly on the line, where the Buckeyes have struggled a bit this season in terms of allowing pressure to get to Julian Sayin. For all of their talent, the Buckeyes are still 70th in rushing success rate, 95th in points per quality possession and 98th in third- and fourth-down success rate. Given that this is a very difficult environment for a young quarterback making his first true road start, I have to side with the home underdog and take the points in this one.

Ohio State vs Washington prediction: Washington Huskies +9.5 available at time of publishing. Playable to Washington +8.5

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This is a pretty correlated handicap, as this game going over the total should pair nicely with the Huskies covering the spread. For starters, we know that Ohio State has likely been saving a few bullets in the chamber for Big Ten play, and that the Buckeyes will probably be able to score in the upper 20s at least against a solid, yet unspectacular Washington defense. Then, there’s also the matter of the Washington offense, which is currently one of the most efficient units in the nation (9th in success rate, 1st in points per drive and third- and fourth-down success rate). If the Huskies are going to hang around at home, they’re going to have to get off to a strong start and put up at least 21-24 points in a game that should come down to the final quarter. The over is the only way I can look in this matchup.

Ohio State vs Washington prediction: Over 51.5 available at time of publishing. Playable to 53.