Old Dominion Monarchs vs Virginia Tech Hokies Prediction, Odds and Picks for Today, 09/13/25

The Old Dominion Monarchs head to Blacksburg looking to add to the headaches of the Virginia Tech Hokies and their faithful. Old Dominion has been a thorn in the side of Virginia Tech since these two started playing each other back in 2017. Old Dominion has won outright twice, although each of those upsets took place in Norfolk. Virginia Tech posted a 37-17 victory last season in the Tidewater, but the way things are looking in Blacksburg, ODU is quite attractive.

Old Dominion has covered both of its games so far, including a 27-14 loss at Indiana to open the season. The Hoosiers needed a punt return for touchdown in that one, as the 2024 playoff participants had their hands full with the Monarchs. Virginia Tech head coach Brent Pry is on the hot seat, and it will be turned up to Venus-like temperatures if he can’t dispatch the Monarchs. Virginia Tech lost 24-11 to South Carolina in a neutral-site game to open, and it was blown out 44-20 against perennial SEC doormat Vanderbilt last week in Blacksburg. The Hokies are 0-2 ATS so far, and winless outright. It’s hard to believe, but Old Dominion looks like the more cohesive unit, and it is the play on the road, unless Va. Tech shows some consistency.

Old Dominion vs Virginia Tech prediction: Old Dominion +6 (-110) at time of publishing. Playable to +5.5.