Oregon Ducks vs Northwestern Wildcats Prediction, Odds and Picks for Saturday, 09/13/25

A week ago, I laid four touchdowns with Oregon in what was an ideal spot against Oklahoma State, and that will likely be one of the easiest winners I’ll have all season long as the Ducks put up 69 points on the Cowboys in a dominant victory from start to finish. It’s been nearly a picture-perfect start to the campaign for Dante Moore and company to this point. In fact, there have been more than half a dozen Ducks players that have registered touchdowns over the first 2 weeks in a pair of total beatdowns against historically proud programs. Now, Dan Lanning’s team heads to Chicago for a date with Northwestern on Lake Michigan in what could be a very sleepy spot for the Ducks with a rivalry game against Oregon State on deck, followed by a massive matchup against Penn State in Happy Valley.

Given the fact that this is a clear sandwich spot for Oregon and kickoff is set for 9 a.m. on the west coast, its hard to see the Ducks offense setting the world on fire in this one. Yes, it’s going to be difficult for Northwestern’s defense to make plays in the open field against the likes of Dakorien Moore or Kenyon Sadiq, but the Wildcats defense has been really solid against the run to this point and has been good at getting off the field on 3rd downs. On the other side of the ball, Oregon’s defense has been virtually flawless to this point, but this is an instance where the Northwestern offensive game plan is one that should focus on establishing the ground game and shortening the game. Look for Preston Stone and the Wildcats to chew up plenty of clock and try and slow this game down to a crawl in order to avoid a bludgeoning at the hands of a much more talented Oregon team. It’s not for the faint of heart, but let’s back the ‘Cats to keep this game within 4 touchdowns at home.

Oregon vs Northwestern prediction: Northwestern +28.5 available at time of publishing. Playable to 28.

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