Penn State Nittany Lions vs UCLA Bruins Prediction, Odds and Picks for Today, 10/04/25

The Penn State Nittany Lions are likely champing at the bit to get back on the field after falling to the Oregon Ducks in double-overtime in Happy Valley in a marquee battle last weekend. After facing the likes of Nevada, FIU and Villanova in the first 3 weekends, Penn State’s defense was mortal against an actual Power 4 contender. The Nittany Lions head into Saturday’s game at the Rose Bowl with an 0-4 against the spread (ATS) record, while the over is 3-1 in 4 games to date, if you’re into Same-Game Parlay (SGPs) wagering.

UCLA has had a trying season already. The Bruins suffered a 43-10 loss at home against Utah in a Pac-12 reunion on August 30th before losing 30-23 at UNLV as a 1.5-point favorite on September 6th. They returned home on a Friday night to suffer an embarrassing 35-10 loss against New Mexico despite being a 16-point favorite. UCLA ended up firing head coach Deshaun Foster, a Bruins alum, officially throwing in the towel. Under interim coach Tim Skipper, UCLA put up a fight at Northwestern, falling 17-14 as a 6.5-point underdog, while the under (46) cashed. Despite the Bruins being more competitive last week, the Nittany Lions are going to be angry, starting quickly, while washing the bad taste out of the mouths with a whitewashing of the Bruins.

Penn State vs UCLA prediction: Penn State Nittany Lions -24.5 (-110) at time of publishing. Playable to -26.5.

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