Purdue Boilermakers vs Washington Huskies Prediction, Odds and Picks for Today, 11/15/25

We’ve got a Big Ten battle in the Pacific Northwest on Saturday when the Washington Huskies play host to the Purdue Boilermakers in Seattle. This is a good spot to back a Washington team that just had its worst performance of the season a week ago against Wisconsin, a game in which the Huskies only scored 10 points and lost as a double-digit favorite. However, Jedd Fisch’s team did outgain Wisconsin and was minus-2 in turnovers in a game that was played in pretty adverse weather conditions. that result tracks with how the campaign has gone for Washington, as the Huskies have one of most extreme discrepancies in home and road performances of any team in the country this season. While the Huskies haven’t been great on the road by any means this season, this is still one of the best home field advantages in the sport and it should claim another victim on Saturday.

This is a spot where I have real matchup concerns for a Purdue team that has struggled defensively all season long. After all, this is a Purdue defense that is 122nd in success rate allowed, and the Washington offense is one of the top 10 units in the sport (5th in success rate, 7th in quality drive rate, 6th in third down success rate). The Huskies have been a machine at home, and I’m of the belief that Demond Williams Jr, Jonah Coleman, Denzel Boston and company should be able to generate success against an Purdue defense that is 130th in quality drive rate allowed and 103rd in points per drive allowed. While Washington’s defense isn’t elite by any means, the Purdue offense has been extremely poor in recent weeks, so I don’t think the Boilermakers will be able to keep up with a Huskies team that has as good of an offense as almost any team across the nation when playing at home. Ultimately, I’ll lean on the hosts to win and cover this number in what should be a blowout in Seattle. 

Purdue vs Washington prediction: Washington -16.5 available at time of publishing. Playable at that number. 

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