Rutgers Scarlet Knights vs Ohio State Buckeyes Prediction, Odds and Picks for Today, 11/22/25

The Rutgers Scarlet Knights hit the road for Columbus to battle the top-ranked Ohio State Buckeyes at The Horseshoe. It’s the penultimate game of the season for both teams. Rutgers has 5 victories this season, and it needs a win against the Buckeyes or at home against Penn State next Saturday to qualify for a bowl game. Rutgers has won 2 of the past 3 games to keep its postseason hopes alive, while also going 2-1 ATS. The under has cashed in each of the past 3 games, too, while going 4-1 in the past 5 outings. The Scarlet Knights have scored 19 or fewer points in 3 of the past 5 games.

For the Buckeyes, they’ve allowed 10 or more points in 3 straight games, but they’re still allowed 75 points all season, or 7.5 points per game. The under is 3-2 in the past 5 games, and 5-3 across the past 8 outings. However, at home, the over is 3-0 in the past 3 conference games at the Horseshoe, and 4-1 in the past 5 home games dating back to September 6. Ohio State has dominated this series since Rutgers joined the Big Ten, winning all 10 meetings since October 18, 2014, while the over has connected in 5 straight outings. Ohio State has scored 49 or more points in 9 of the past 10 meetings, with the lone exception a 35-16 victory in the most recent battle on November 4, 2023 in Piscataway. Go high, and feel confident in doing so.

Rutgers vs Ohio State prediction: Over 55.5 (-110) at time of publishing. Playable to 56.5.

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