San Jose State Spartans vs San Diego State Aztecs Prediction, Odds and Picks for Saturday, 11/22/25

The San Jose State Spartans hit the road for Snapdragon Stadium to battle the first-place San Diego State Aztecs, who can clinch a spot in the Mountain West Conference championship game with a win. Don’t expect San Diego State to take its foot off the gas and suffered a letdown. San Diego State bounced back nicely in the rain last week against Boise State, winning 17-7, a good win after a debacle in the islands, when it lost 38-6 at Hawaii. The Aztecs are still 7-1 straight up (SU) in the past eight games, and they’re also 7-1 against the spread (ATS) in the span, with the only non-cover in the islands. The Under is 4-0 in the past four games, too, as the defense has been on point for San Diego State. It has allowed 10 or fewer points in four of the past five games, and it has three shutout wins, while allowing 10 or fewer points on seven occasions.

The Spartans are no longer eligible for a bowl after losing their seventh game of the season at Nevada last week, 55-10. It has allowed 26 or more points in nine consecutive games, and San Jose State has dropped four of the past five games, while going 1-4 ATS, if you’re looking for a same-game parlay (SGP). But, San Jose State has scored just 13.0 PPG in the past two games, and against San Diego State, it won’t get much better. Look for a rout for the Aztecs, and go with the Under, too.

San Diego State -11.5 (-110) at time of publishing. Playable to -13.5.