San Jose State Spartans vs San Diego State Aztecs Prediction, Odds and Picks for Today, 11/22/25

The San Jose State Spartans hit the road for Snapdragon Stadium to battle the first-place San Diego State Aztecs, who can clinch a spot in the Mountain West Conference championship game with a win. Don’t expect San Diego State to take its foot off the gas and suffered a letdown. San Diego State bounced back nicely in the rain last week against Boise State, winning 17-7 – a good win after a debacle in the islands when it lost 38-6 at Hawaii. The Aztecs are still 7-1 SU in the past 8 games, and they’re also 7-1 ATS in the span. The under is 4-0 in the past 4 games, too, as the defense has been on point for San Diego State. It has allowed 10 or fewer points in 4 of the past 5 games, and it has 3 shutout wins while surrendering 10 or fewer points on 7 occasions.

The Spartans are no longer eligible for a bowl after losing their 7th game of the season at Nevada last week, 55-10. It has allowed 26 or more points in 9 consecutive games, as San Jose State has dropped 4 of the past 5 contests while going 1-4 ATS. However, San Jose State has scored just 13.0 PPG in the past 2 games, and against San Diego State, it won’t get much better. Look for a rout for the Aztecs, and go with the under, too.

San Jose State vs San Diego State prediction: San Diego State Aztecs -11.5 (-110) at time of publishing. Playable to -13.5.

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