SMU Mustangs vs Boston College Eagles Prediction, Odds and Picks for Saturday, 11/08/25

From a situational perspective, this is about as good of a spot as you can find on the Week 11 slate — and I intend to take advantage of it. On one side, Boston College comes into this game in a fine run of form against the number following a pair of covers in back-to-back contests against Louisville and Notre Dame. The Eagles are in the midst of a very disappointing season, having only won a single game to this point, but this is still a well-coached unit that has battled the best teams on its schedule tooth and nail in recent weeks. Bill O’Brien should have his team prepared to play in what is one of the final home games of the season for Boston College.

Conversely, SMU is in a brutal letdown spot after knocking off Miami at home in what was clearly the biggest win of its season to this point. Now, head coach Rhett Lashlee’s side will have to travel all the way to the northeast for a bizarre matchup against a new conference foe in Boston College, a team they couldn’t possibly care all that much about, all while staring at a massive home game against Louisville on deck that could have massive implications in the ACC title picture. It shouldn’t surprise anyone if the Mustangs come out very flat in a spot in which they could still be a bit hungover from last week’s win season-altering victory against Miami that was a massive bounce-back performance following a loss to Wake Forest the week prior. With that in mind, it wouldn’t surprise me at all if Boston College kept this game within one score and really put a scare into the visitors, so I’ll certainly take the points with the Eagles at home in a matchup that should be closer than what the market expects.

SMU vs Boston College prediction: Boston College +11.5 available at time of publishing. Playable to 10.5

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