South Alabama Jaguars vs Auburn Tigers Prediction, Odds and Picks for Saturday, 09/13/25
South Alabama vs Auburn Pickswise Expert Predictions
Look-ahead spots seem to be a theme in Week Three, and Auburn fits the mold perfectly. On deck for the Tigers is a massive showdown with Oklahoma, a game that will carry both conference and Top 25 implications. That matchup is the priority. The onus this week isn’t on Auburn to win emphatically but simply to handle business and avoid injuries before heading to Norman.
Head coach Hugh Freeze understands the stakes. He isn’t likely to show much on tape with the Sooners looming, which makes Auburn coasting through this contest the most probable scenario. That leaves a wide opening for South Alabama to sneak in under the number.
The Jaguars, meanwhile, aren’t a pushover. This is a program that has consistently played winning football in recent seasons and will be fully up for this challenge. Just last week, South Alabama went toe-to-toe with Tulane in a 33–31 shootout, a game they will feel they should have won. The Jaguars can score at a good clip, and while Auburn’s defense looks formidable on paper, it only takes a few successful drives to flip the math. If USA can post two or three touchdowns, Auburn would need to score into the 40s to cover this spread. We are not sure Auburn cares about doing that, as the biggest game in recent memory sits on the horizon. With Oklahoma looming, Auburn has little incentive to push the pace or pour on points late. Style points won’t matter nearly as much as getting to next week ready to roll against a vastly improved Oklahoma team.
South Alabama brings enough offense to stay competitive for stretches and enough fight to push Auburn in sequences. Add in the situational dynamics, and this is the perfect environment for the underdog to come in under the number.
South Alabama vs. Auburn prediction: South Alabama +25.5 (-110) at the time of publishing. Playable to 25.
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