South Florida Bulls vs Miami Hurricanes Prediction, Odds and Picks for Saturday, 09/13/25

The South Florida Bulls are on the road for a second consecutive game inside the Sunshine State. USF pulled off the big road upset at Florida, winning on a last-second field goal in The Swamp, 18-16, cashing as an 18-point underdog. The Bulls are a similar underdog in this game against another ranked foe. Lost in the good start, with two wins over ranked teams, is the defensive effort of USF. It topped Boise State 34-7 in the opener as a 4.5-point underdog, and the Under has cashed in both outings, in case you’re considering a Same-Game Parlay (SGP).

The Hurricanes went to Tampa last season and belted the Bulls 50-15 as a 16.5-point favorite as the total (65) pushed at most shops. The Bulls would love to exact a little revenge, and they enter the game playing with a ton of confidence. However, Miami knows a little bit about confidence, too. It topped Notre Dame in the opener, while routing FCS Bethune Cookman last week, although it didn’t come close to cashing as a 53.5-point favorite. QB Carson Beck has completed 76.4 percent of his passes for 472 yards, four touchdowns and no interceptions through two starts. RB Mark Fletcher Jr. is off to a good start with 5.8 yards per carry and two touchdowns. He will be a difference maker, helping The U avoid the upset. However, this is a lot of points to lay. Take the Bulls, who are running with a lot of confidence.

USF +17.5 (-110) at time of publishing. Playable to +17.