South Florida Bulls vs Miami Hurricanes Prediction, Odds and Picks for Today, 09/13/25

The South Florida Bulls are on the road for a second consecutive game inside the Sunshine State. USF pulled off the big road upset at Florida, winning on a last-second field goal in The Swamp, 18-16, and cashing as an 18-point underdog. The Bulls are a similar underdog in this game against another ranked foe. Lost in the good start, with 2 wins over ranked teams, is the defensive effort of USF. It topped Boise State 34-7 in the opener as a 4.5-point underdog, and the under has cashed in both outings, in case you’re considering a Same-Game Parlay (SGP).

The Hurricanes went to Tampa last season and belted the Bulls 50-15 as a 16.5-point favorite, as the total (65) pushed at most shops. The Bulls would love to exact a little revenge, and they enter the game playing with a ton of confidence. However, Miami knows a little bit about confidence, too. It topped Notre Dame in the opener, while routing FCS Bethune Cookman last week, although it didn’t come close to cashing as a 53.5-point favorite. QB Carson Beck has completed 76.4 percent of his passes for 472 yards, 4 touchdowns and no interceptions through 2 starts. RB Mark Fletcher Jr. is off to a good start with 5.8 yards per carry and 2 touchdowns. He will be a difference maker, helping The U avoid the upset. However, this is a lot of points to lay. Take the Bulls, who are running with a lot of confidence.

USF vs Miami prediction: USF +17.5 (-110) at time of publishing. Playable to +17.

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The No. 18 South Florida Bulls have been playing with tremendous confidence in their first 2 games, topping the ranked Boise State Broncos and the ranked Florida Gators. USF belted the Broncos 34-7 at Raymond James Stadium in the opener, allowing 378 total yards and 5.3 yards per pass attempt. They also limited the Broncos to just 3.2 yards per rushing attempt, while forcing 3 turnovers. USF had a little bit of a bend-don’t-break defense in that one, and it took advantage of all miscues. USF allowed 25 first downs, while managing just 15 on offense, and it was 5-of-14 in third-down efficiency. It gave up 355 total yards to Florida, and it also forced 1 turnover while taking good care of the ball.

Miami will have a tough time corralling QB Byrum Brown, who is a fabulous dual-threat option. The Bulls are pretty good running the ball, and, in fact, it is their specialty. Running teams run the clock, which under bettors love. Miami threw a blanket on Bethune Cookman last week, giving up just 3 points. It will get a much bigger test here. While Miami allowed 314 total yards to Notre Dame, it was hard on the run, while managing just a 5-of-14 mark in third-down efficiency. Against another ranked team, the Hurricanes could struggle to roll up big yards on offense. This game has the feel of a 31-17 kind of a game, meaning it has the look and feel of an Under play.

USF vs Miami prediction: Under 57.5 (-110) at time of publishing. Playable to 57.

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