Stanford Cardinal vs Miami Hurricanes Prediction, Odds and Picks for Today, 10/25/25

Saturday’s game in the ACC features a pair of teams coming off very different results. On one side, the Miami Hurricanes were just upset by the Louisville Cardinals in a game where the Hurricanes were favored by nearly 2 touchdowns at home. They didn’t just lose to Louisville as a significant favorite, they were significantly outplayed for the majority of the game and had a whopping 4 turnovers in the loss. On the other side of the coin, Stanford continued its surprisingly solid run of form of late with a win over Florida State as a massive 18-point home underdog. However, while the Cardinal were undeniably impressive in that contest, you have to factor in the fact that Florida State might have quit on the season at this point, and the effort from Mike Norvell’s team certainly didn’t look like one that was playing for their coach. Even with all of that, the Cardinal did not have a high postgame win expectancy in the slightest, which doesn’t bode well for this matchup.

On paper, this is about as big of a mismatch as you can find in the ACC, as Miami certainly has the most talent in the conference while Stanford is fielding a team that was projected to win 2 or 3 games this season. The metrics certainly back that up, with the Hurricanes sitting inside the top 10 in EPA per play on both sides of the ball, while Stanford is 88th in EPA per play and 124th in offensive success rate (CFB-Graphs). The defensive metrics for the Cardinal are ghastly, as Stanford is outside the top 100 in success rate allowed and Early Downs EPA. Miami should be able to name its score in this game, and I’d expect a bounce-back effort from Carson Beck and the ‘Canes offense at home on Saturday. Lay the big number with the hosts.

Stanford vs Miami prediction: Miami -29.5 available at time of publishing. Playable to 30.

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