Stanford Cardinal vs SMU Mustangs Prediction, Odds and Picks for Today, 10/11/25

The Stanford Cardinal hit the road for Dallas to battle the SMU Mustangs in an ACC battle. Stanford has split its first 2 games inside the conference, falling at Virginia, while topping Boston College at home. The Cardinal are 1-4 against the spread (ATS) in 5 games to date, while the over has cashed in each of the past 3 outings. The defense has allowed at least 20 points in each of their 5 games, while the Cardinal have averaged 25.0 PPG on offense and 34.0 PPG allowed on defense in 2 conference games. The over is 2-0 inside the league.

For SMU, it isn’t on track to repeat as a playoff team this season. It suffered a 48-45 OT loss earlier in the season against Baylor, while falling 35-24 at TCU on Sept. 20. The Mustangs won their first conference game against Syracuse last Saturday 31-18, but it failed to cover as 17.5-point favorites. SMU is 0-5 ATS so far this season, while the under has cashed in each of the past 3 games and 4 of 5 games overall. With the total trends all over the place, the best way to go is taking Stanford with the points, as SMU has yet to cash in 5 games to date, including 0-4 ATS as a favorite.

Stanford vs SMU prediction: Stanford Cardinal +19.5 (-110) at time of publishing. Playable to +17.5.

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