Tulane Green Wave vs Ole Miss Rebels Prediction, Odds and Picks for Today, 09/20/25

The Tulane Green Wave come crashing into Oxford to play the Ole Miss Rebels in a battle of two undefeated teams on Saturday. The Green Wave have already beaten two power conference opponents in this young season, dismantling Northwestern in Week 1, 23-3, before outlasting Duke last week despite being outgained, surrendering 5.8 yards per rush attempt, and racking up 100 penalty yards. While Jake Retzlaff was great for the Green Wave in the win over the Blue Devils, if those trends continue, the trip to the Grove may not be very friendly to Tulane.

As for Ole Miss, quarterback Austin Simmons is expected to return on Saturday, but the Rebels are in quite an interesting spot here. They’ve already played two conference opponents in Kentucky and Arkansas, beating both by just one score, and now they have this odd non-conference game against a regional “little brother” ahead of a massive showdown with LSU next weekend. It’s definitely a tricky situation, but I have a feeling Lane Kiffin will have his team ready to fight – not looking ahead to LSU. Kiffin knows just how tough Jon Sumrall and the Green Wave are considering his Rebels played against Sumrall’s Troy squad in 2022 and at Tulane in 2023.

This line opened around 13 points and was bet down. I get it; Tulane has beaten two Power Four teams, and quarterback Retzlaff has looked invincible at times – especially as a runner. However, I can’t get over how poorly the Green Wave played defensively since their impressive win over Northwestern. At South Alabama, they allowed over 250 yards of total offense on four second-half drives – three of which resulted in points. The Green Wave followed that up with a poor defensive showing last week against Duke, allowing more than 450 yards. This Ole Miss offense will be, by far, the most talented offense Tulane has seen to this point, and I expect the Rebels to name their score no matter who is playing under center on Saturday.

Don’t get me wrong, Ole Miss’ defense hasn’t been good, but there is a fairly wide talent disparity between these two rosters, and Tulane hasn’t shown much consistency offensively outside of what Retzlaff has been able to do as a runner. Against AAC competition, I expect Ole Miss’ front seven to look better than it did last week, and for the Rebels skill players to be too much to handle for the Tulane defense. Retzlaff won’t be able to do it alone in this one. ‘Rebs roll at Vaught-Hemingway Stadium, improving to 14-5-1 ATS as a non-conference favorite under Kiffin.

Tulane vs Ole Miss prediction: Ole Miss Rebels -10.5 (-110) at the time of publishing. Playable to -13.

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