UCLA Bruins vs Ohio State Buckeyes Prediction, Odds and Picks for Today, 11/15/25

The UCLA Bruins travel east to meet the Ohio State Buckeyes at Ohio Stadium in Columbus under the lights on Saturday. UCLA had a nightmare start to its season, and it ended up firing head coach Deshaun Foster after the 35-10 loss to New Mexico after an 0-3 start. It tabbed Tim Skipper as the interim head coach, and the former head man at Fresno State has led an impressive turnaround. UCLA is 3-3 under Skipper, including a 42-37 win over Penn State on October 4 as a 25-point underdog. It put up a fight last Saturday, falling 28-21 against Nebraska as a 2-point favorite, which likely ended a potential run to an improbable bowl.

Ohio State routed Purdue 34-10 in West Lafayette last weekend, but the big story was the non-cover. It was a 28.5-point favorite, but it failed to cover for the first time after opening the season 7-0-1 ATS in the first 8 games. UCLA will have a difficult time moving the ball on Ohio State, which has allowed just 33 points in 5 games at home this season. It would be shocking to see the Bruins score more than 10 points. At home, Ohio State has scored at least 37 points in each of the past four outings. However, as a favorite of 28 or more points, it is just 1-1-1 ATS this season. Let’s take UCLA, but go lightly.

UCLA vs Ohio State prediction: UCLA Bruins +32 (-110) at time of publishing. Playable to +31.

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