UNLV Rebels vs Wyoming Cowboys Prediction, Odds and Picks for Today, 10/04/25

Dan Mullen and the UNLV Rebels hit the road for Laramie for their first Mountain West Conference game. After a subpar effort against FCS Idaho State in the opener, winning just 38-31, the Rebels have picked up the pace. They routed Sam Houston State 38-21 on the road, before topping UCLA 30-23 at home as a 1.5-point underdog. Last week, after a bye, UNLV hit to road for Miami (OH), engineering a comeback 41-38 win and cover as a 1.5-point favorite. The over (49.5) easily came through in that one. Defense is a bit of a concern for UNLV, but the offense, led by QB Anthony Colandrea, has more than enough firepower to overcome the deficiencies of the defense.

For Wyoming, offense has been a bit shaky this season. While the Cowboys have split 4 games, going 2-2, those victories came against Akron in a 10-0 road win, and against FCS Northern Iowa. Against 2 Power 4 teams, Wyoming was beaten 31-6 by Utah, and 37-20 at Colorado last time out, failing to cover in either outing. In addition, that’s a losing margin of 21.0 points per game. The Cowboys defense should struggle with Colandrea and the high-octane UNLV offense, and even with the struggles of the Rebels on defense, Wyoming doesn’t have the firepower to get involved in a shootout.

UNLV vs Wyoming prediction: UNLV Rebels -3.5 (-110) at time of publishing. Playable to -5.5.

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