HomeCollege FootballCollege Football PredictionsUSC Trojans vs Illinois Fighting Illini Prediction, Odds and Picks

USC Trojans vs Illinois Fighting Illini Prediction, Odds and Picks for Saturday, 09/27/25

Updated: 5:00 AM ET Sep 28, 2025

Memorial StadiumFOX

4-0

USC

12:00 PM ETSat Sep 27

3-1

Illinois

Caleb Wilfinger

Updated: 5:00 AM ET September 28, 2025

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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.

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