HomeCollege FootballCollege Football PredictionsUSC Trojans vs Notre Dame Fighting Irish Prediction, Odds and Picks

USC Trojans vs Notre Dame Fighting Irish Prediction, Odds and Picks for Saturday, 10/18/25

Updated: 5:00 AM ET Oct 19, 2025

Notre Dame StadiumNBC

5-1

USC

7:30 PM ETSat Oct 18

4-2

Notre Dame

Caleb Wilfinger

Updated: 5:00 AM ET October 19, 2025

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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.

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