Utah Utes vs Wyoming Cowboys Prediction, Odds and Picks for Saturday, 09/13/25

The Utah Utes travel to Laramie to face the Wyoming Cowboys on Saturday night. Utah was picked to finish in the middle of the pack in the Big 12 in the preseason, mostly because of a lot of unknowns. But the Utes are off to a hot start, including smashing UCLA by more than 30 points in the opener. Wyoming is coming off a 3-9 season, and I would not be entirely certain the Cowboys will do much better this year if they didn’t already have 2 wins under their belt and get to avoid Boise State on the conference schedule. Still, I think Utah is much, much better — so I am backing the Utes to cover on Saturday, although I think we might want to be cautious since this is a classic road-game trap spot.

Wyoming has a very straightforward approach to the game: keep the ball on the ground as much as possible, and when you do have to throw it, throw it to the tight end. Indeed, the best player on the team is TE John Michael Gyllenborg. The problem with that approach is that Utah head coach Kyle Whittingham always has an elite defense, and this one might be one of his best. I don’t see the Cowboys finding much of any success against this Utes defense. On the other side of the ball, the Wyoming defense was one of the worst in the country last year — and that is bad news when facing a better-than-expected Utah offense. Cam Rising is (finally) gone, and they have moved on to Devon Dampier at QB. Dampier came over to Utah with his coach and new OC from New Mexico, where Dampier was the nation’s leading rushing QB that wasn’t at a service academy. That is a great fit for Utah’s run option offense, especially behind an offensive line in which all 5 guys returned from last year’s squad. I think Utah can be really good this year, and although Laramie is an oddly difficult place to play, the separation between these 2 teams is vast.

Utah vs Wyoming prediction: Utah -23.5 (-110) available at time of publishing. Playable at that number.

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