UTSA Roadrunners vs South Florida Bulls Prediction, Odds and Picks for Thursday, 11/06/25

The UTSA Roadrunners and South Florida Bulls meet at Raymond James Stadium in Tampa in an American Conference battle on Thursday night. The Roadrunners picked up a surprising 48-26 win as a 5.5-point underdog against Tulane last time out last Thursday, cashing the Over (54.5) for a third straight game. The Over is 6-2 in eight games for UTSA, as it has managed 459.6 total yards, 203.7 rushing yards and 32.0 PPG, which allowing 459.0 total yards, 289.6 passing yards and 30.9 PPG. A lot of scoring, and a lack of defense, is a tremendous recipe for the Over.

For USF, it suffered a crushing 34-31 loss at Memphis on Oct. 25 as a ranked team, potentially having fumbled away any chance at a playoff spot along the way. The Bulls have been tremendous on offense, going for 31 or more points in five in a row, and at least 48 points in four of those outings. The defense has allowed 26 or more points in three of the past four games, too, with the total going high in five of the past six games. QB Byrum Brown and the Bulls should be able to rack up a ton of points against the very giving Roadrunners. Look for UTSA to get theirs, too, though. The number is rather scary being so high, but we should get into the 70’s in Tampa on a crisp, dry night.

UTSA vs USF pick: Over 68.5 (-110) available at time of publishing. Playable to 70.

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