Washington Huskies vs Michigan Wolverines Prediction, Odds and Picks for Saturday, 10/18/25

It’s not the biggest matchup on the board, but one of the biggest games in Big Ten on Saturday comes in Ann Arbor, Michigan, where the Wolverines will host the Washington Huskies at the Big House. Last week, I was all over USC in a clear fade of Michigan in a bad spot, and the Wolverines were never truly in that game against a Trojans offense that sliced and diced their way through the Michigan defense. While the prevailing thought would be to back the Wolverines in a bounce-back spot at home, I’m more inclined to look toward Washington in a game where I have real matchup concerns for Michigan for a second straight week.

While Michigan’s defense has typically been the strength of the team in recent seasons, I have a hard time seeing this Wolverines unit producing against a Washington offense that is 11th in success rate, 10th in passing success rate, 6th in 3rd and 4th down success rate, 2nd in quality drive rate and 17th in points per drive (CFB-Graphs). Outside of a difficult game against Ohio State — arguably the best defense in the country — this has been an excellent unit, and I’m of the belief that Demond Williams Jr, Jonah Coleman, Denzel Boston and company should be able to generate success against a Michigan defense that is shocking poor in the secondary (80th in passing success rate allowed). The Wolverines just struggled mightily against the dynamic USC offense, and while Washington doesn’t necessarily pose the same challenges as USC’s elite passing game, this is still an offense that can put up points in bunches and has as good of a 2-headed monster in the backfield as any team across the nation. 

On the other side, while Bryce Underwood is undoubtedly a talent worthy of the massive hype, he hasn’t been all that effective when Michigan has had to step up in class this season. The Wolverines could be without Justice Haynes in this game, which would be a massive blow against a Washington run defense that has been surprisingly stout in that department this season (16th in EPA per rush, 33rd in rushing success rate allowed). Regardless of if Haynes suits up, the Michigan passing game still looks like a pretty broken operation, and while he should see some success against Washington’s middling pass defense, I just don’t see any difference makers  in this wide receiver room. Ultimately, I’ll lean on the visitors to keep this game within a possession in what should be a competitive matchup from start to finish.

Washington vs Michigan prediction: Washington +6.5 available at time of publishing. Playable to Washington +6. 

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