Washington Huskies vs UCLA Bruins Prediction, Odds and Picks for Saturday, 11/22/25

Following a 49-13 win over Purdue, the 7-3 Washington Huskies will head to southern California to play the 3-7 UCLA Bruins. Meanwhile, the Bruins come into this game after being beat down by the Ohio State Buckeyes in Columbus. It was the 3rd straight loss for the Bruins, who were without starting QB Nico Iamaleava in the contest. Iamaleava participated in drills on Tuesday, so he could return from concussion on Saturday. However, regardless of his status, I like the Huskies in this battle of former Pac-12 foes. 

Washington certainly hasn’t fared well on the road this year, but not all road games are created equal in the Big Ten nowadays. The Huskies’ worst road performances were all in the central and eastern time zones, but they won’t leave the west coast for this one – which has to be a relief. While the Huskies haven’t been the most reliable ATS as a favorite either, I power rate them as 14-point favorites in this matchup. 

When you look at the numbers, it makes sense. The Bruins haven’t been good on either side of the ball of late. In fact, they are outside the top 100 in PPA per play and points per quality drive on both offense and defense. Compare that to Washington, who is top-35 offensively and top-20 defensively in the aforementioned metrics. Moreover, Washington has reached the red zone 14 more times than UCLA this year and boasts the 3rd-best red-zone touchdown rate nationally – punching it into the end zone on 33 of 42 trips across the opposing 20-yard line. That smells like trouble for Bruins, who rank 133rd in red-zone touchdowns allowed (33) and 135th in opposing red-zone touchdown rate (78.57%). Look for the Huskies to name their score and cruise to a win and cover.

Washington vs UCLA prediction: Washington Huskies -10 (-115) available at the time of publishing. Playable to -12.5.  

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