West Virginia Mountaineers vs Kansas Jayhawks Prediction, Odds and Picks for Today, 09/20/25

The West Virginia Mountaineers hit the road again Saturday, this time for their Big 12 conference opener. The Mountaineers will face the Kansas Jayhawks, a team raring to get back on the field after a loss to rival Mizzou last time out in Columbia. West Virginia earned an emotional 31-24 win over Pittsburgh in the Backyard Brawl, washing the bad taste out of its mouth after a 17-10 loss at Ohio as 3.5-point favorites. The Mountaineers feel better about all aspects of their team after the win over Pitt. The under has cashed in all three games for WVU, while going 2-1 ATS.

For Kansas, it is just 1-9 SU in the past 10 meetings in this series since Oct. 4, 2014, although it is 6-1-1 ATS in the past eight meetings. However, the Jayhawks have never been favored in those 10 meetings, so it’s an eyebrow-raiser that KU is favored by nearly two touchdowns at most shops. The Jayhawks have scored 31 or more points in all three games to date, including a 42-31 loss at Mizzou. This West Virginia defense will be the best one it has seen yet. If you’re into SGPs, going low on the total is a good play, but make sure to take the Mountaineers with the points, especially if you can get it at a flat 14 at some point.

West Virginia vs Kansas prediction: West Virginia Mountaineers +13 (-110) at time of publishing. Playable to +11.5.

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