Western Kentucky Hilltoppers vs Louisiana Tech Bulldogs Prediction, Odds and Picks for Today, 10/21/25

The Western Kentucky Hilltoppers head down to Joe Aillet Stadium in Ruston, Louisiana looking for redemption after getting absolutely runover in unexpected fashion by visiting FIU last week, suffering their first loss of Conference USA play. It had previously been smooth sailing for the ‘Toppers, as they were not only 3-0 inside the league, but also 3-0 against the spread (ATS) against C-USA opponents. In fact, Western was 5-1 ATS in the previous six games before FIU came to town and won outright as a 10-point underdog. Nobody saw that coming, even FIU’s biggest support, singer Pitbull.

As far as Louisiana Tech is concerned, it is smack-dab in the middle of the C-USA chase, but it is also coming off a stunning loss. The Bulldogs were also unbeaten in league play, and favored last week, and, like WKU, they were also manhandled. Louisiana Tech was belted 35-7 at Kennesaw State last week as a 4.5-point favorite, snapping a 3-game win streak, while suffering its first non-cover of the season. The Under is 5-1 on the season for LT, while the Under has cashed in four in a row for WKU. Since both teams are a bit hard to figure at the moment, after separate stunning losses, and the Under trend is pretty clear, we’ll lean low on the total. But, if you were looking for an SGP opportunity, WKU and the points with the Under is the way to go.

Under 50 (-110) at time of publishing. Playable to 48.5.