MLB Best Bets

Welcome to the home of our MLB best bets. Our expert handicappers analyze all of the latest team news, statistics, form, and trends to bring to you our MLB best bets. For the remainder of our MLB picks, including a pick for each game of the MLB season, head over to our MLB Picks and MLB Predictions pages.

Our MLB best bets will be released at the latest at 11 am EST once all lines have become available with sportsbooks.

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Money Line (1)

Experts

Pickswise Experts (2)

7:10 PM ETToday

Money Line Pick

PHI Phillies Win(-115)PHI Phillies @ NY Mets

Reasoning

After jumping out to an early 3-0 lead, the Mets’ offense exploded, putting up 13 runs over the last five innings of the game. The Phillies currently hold a six-game lead in the NL East, and this is a series they’re looking to win as they try to keep their division rivals out of the playoff race. The Mets bats have been red-hot as of late, averaging 7.1 runs per game over their last 10, while the Phillies are slightly behind, averaging 6.2 runs per game.

Taking the mound for the Phillies will be the left-hander Jesus Luzardo, who enters with a 12-6 record and 4.10 ERA. Luzardo has had his ups and downs this season, but it looks like he’s found his groove again, going 4-1 with a 2.32 ERA and has struck out 34 batters in his last 31 innings pitched. For the Mets, Sean Manaea will get the start, entering with a 1-2 record and 5.15 ERA. Manaea started this season off strong, but has struggled lately, going 0-1 with a 7.91 ERA in his last four starts. Luzardo has already picked up one victory against the Mets this year, and I think the Phillies will rebound in a big way against the Mets tonight, making them my best bet of the day.

Phillies vs Mets prediction: Phillies ML (-115) available at time of publishing. Playable at that number.

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Jason Fragomeni

9:45 PM ETToday

5 Innings Line Pick

CHI Cubs F5 ML(-135)CHI Cubs @ SF Giants

Reasoning

The Cubs hand the ball to veteran left hander Matthew Boyd, who has quietly been one of the most effective starters in the National League this season. Boyd enters with a strong 12–6 record, 2.61 ERA, and 1.04 WHIP, while consistently limiting hard contact with an average exit velocity against of just 88.2 mph. His ability to control innings was on full display in his recent outing against the Yankees, where he fired eight scoreless frames, scattering four hits with no walks and striking out six. With Chicago’s defense supporting his ground ball tendencies and a lineup capable of manufacturing early runs, the Cubs are in a strong position to strike first. Their offense has been steady of late, with a balanced mix of power and contact hitters giving Boyd the support he needs to work confidently in the early innings.

The Giants counter with Justin Verlander, the future Hall of Famer who has endured a difficult season. Through 22 starts, he owns a 1–10 record and 4.64 ERA, numbers that reflect his inconsistency and decline from peak form. While Verlander has flashed vintage moments and recently surpassed 3,500 career strikeouts, too often he has struggled with command and elevated pitch counts, preventing him from working deep into games. That puts added pressure on a Giants lineup that has been inconsistent and often slow to produce runs against quality pitching. With Boyd in strong form and Verlander struggling to regain rhythm, the advantage early tilts toward Chicago.

Cubs vs Giants Prediction: Cubs F5 ML (-135) available at time of publishing. Playable to -145

BET 0.0 NOW WITH

Justin Ziolkowski

What Are Our MLB Best Bets

At Pickswise our expert handicappers spend hours analyzing each match of the MLB season, delving into the latest MLB statistics, team news, travel, schedule, weather, trends to name just a few angles we cover and consider.

With a typical MLB regular season containing a total of 2,430 games, researching this many games in the required depth is an exhaustive task. Our experts take care of all of that, so you don’t have to.

With a large number of games each day throughout the 2025 season and up to 15 matches on any given day (or sometimes more if there are doubleheaders), being selective in your wagers is key in trying to secure a long-term profit. That’s where our confidence ratings and MLB best bets come into play.

Our MLB Best bets are exactly what you would expect them to be, our top picks for today’s slate of games, with our reasoning and analysis for each MLB Best Bet alongside.

How Do I Know What Your MLB Best Bets Are For Today?

Our MLB best bets for today will appear right here, on our MLB best bets page.

Across our site, our expert handicappers provide the best free MLB predictions and match previews for every game of the MLB season and include a confidence rating for each of our MLB predictions.

The rating system runs from one to three stars, the more stars, the more confidence in the pick, with the most confident MLB Picks highlighted here on our MLB best bets page.

As soon as the sportsbooks release the odds and lines for today’s MLB games our expert handicappers will be combining these with their research to find today’s MLB best bets.

Where Should I Wager On Your MLB Best Bets Today?

MLB is one of the most popular sports that sports bettors place wagers on and as such, most online sportsbooks will offer competitive prices about a plethora of markets on each game.

While we preview every game of the MLB season from Opening Day through to the World Series, betting on every game is not recommended, with a betting strategy very much needed to see you turn a profit over the season.

A big part of this strategy is making sure you are wagering on our MLB Predictions at the best possible odds. With each sportsbook pricing up markets differently, be sure to shop around to make sure you are on our MLB Best Bets at the best odds available.

All of our MLB picks are accompanied by the best available odds and which online sportsbooks are offering them, as well as our detailed reasoning for the pick.

If you don’t yet have an account with one of the sportsbooks listed as having the best odds, why not check out our Sportsbook Bonuses Page to see the latest promo codes available in your state and get off to a flyer with a great sign up bonus. To see our thoughts on the leading online sportsbooks, check out our Online Sportsbook Reviews Page right here.

Baseball Betting – Best Baseball Bets Today

Baseball betting can be tricky with so many games played each day and across the season – 2,340 in just the regular season alone! There are also many different ways that you can wager on baseball betting, from traditional markets like the Money Line, Run Line, and Runs Totals, to MLB Prop Bets such as player runs, hits, and strikeouts, or Team Props such as team runs or innings betting. Our baseball best bets page is the best place to start when looking at your baseball betting today. Here our expert handicappers post their best baseball bets on today’s slate with full analysis, reasoning, and odds. Check out our MLB Predictions and MLB Picks pages for all of our other baseball betting previews and picks.

MLB Lock Of The Day – MLB Lock Picks Today

Looking for MLB Lock Picks today? Well, you’re in the right place. At Pickswise, our MLB Lock picks will be right here on our MLB Best Bets page every day of the regular season and into the MLB playoffs. With 2,430 regular-season games played alone in an MLB season, and numerous games played on any given day, it’s not wise to bet on them all. What you’ll find here is our MLB expert handicappers’ MLB Lock Of The Day, our most confident pick. Each MLB Lock Pick will be accompanied by a full match preview and analysis including why we have this as being a lock. You can also check out how our MLB Lock picks have fared across the season, with our 2025 MLB Best Bets Record displayed at the top of this page.

Be sure to check out our MLB Picks and MLB Predictions for all of our other MLB bets on today’s games.