Arizona Diamondbacks vs Los Angeles Dodgers Prediction, Odds and Picks for Today, 03/27/26

The Dodgers picked up right where they left off, dominating offensively in an 8-2 win to open the season. Andy Pages launched a 3-run homer, while Will Smith added a 2-run shot of his own. This Dodgers lineup is loaded, and with the addition of Kyle Tucker, it becomes even more dangerous for any opposing pitcher, no matter how good they are.  

Taking the mound for the Diamondbacks tonight will be Ryne Nelson who finished last season with a 7-3 record and a 3.39 ERA. Nelson pitched well in Spring Training, going 3-1 with a 3.18 ERA through 17 innings pitched. For the Dodgers, Emmet Sheehan will get the start after going 6-3 with a 2.82 ERA last season. Sheehan had a slow start this spring, allowing 7 runs in 10.2 innings pitched while striking out 11. It’s hard to go against the Dodgers given their depth and firepower, but Arizona’s lineup deserves respect. The Diamondbacks ranked 5th in OPS (.758) last season and feature playmakers like Ketel Marte, Corbin Carroll, Geraldo Perdomo, and Nolan Arenado. They’re all more than capable of generating offense, especially against a pitcher like Sheehan who is still working to find consistency. As we head into the second game of the season, this matchup sets up well for runs on both sides. While the Dodgers are the more talented team, I expect the Diamondbacks to score enough runs against Sheehan as he tries to find his footing, pushing this game over its total. 

Diamondbacks vs Dodgers prediction: Over 8.5 (-115) available at time of publishing. Playable at that number.