Arizona Diamondbacks vs San Diego Padres Prediction, Odds and Picks for Today, 09/26/25

The San Diego Padres will open their final 3-game series against the division-rival Arizona Diamondbacks, and they would like nothing more than knocking their divisional foes out of the playoff race. Taking the mound for the Padres will be Yu Darvish, who enters with a 4-5 record and a 5.51 ERA. Arizona is countering with Zac Gallen, who is 13-14 with a 4.70 ERA. 

Offensively, both teams are fairly even — with the Diamondbacks averaging 4.5 runs per game in their last 10 compared to the Padres 4.6. Gallen has faced the Padres twice this season, going 1-0 with a 2.92 ERA. As for Darvish, he is 0-1 with a 5.87 ERA in 2 starts against Arizona this year. When you look at these 2 starters, Gallen has been the stronger pitcher, and the Diamondbacks have the power on offense to get to Darvish early on. Arizona is fighting for its life to make the final NL wild-card spot and should live to see another day after picking up a win over San Diego.

Diamondbacks vs Padres prediction: Arizona ML (+120) available at time of publishing. Playable at that number.

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