Arizona Diamondbacks vs San Francisco Giants Prediction, Odds and Picks for Today, 09/09/25

After Monday’s 11-5 victory, the Giants have now won three straight games against the Diamondbacks this season. San Francisco’s Robbie Ray will get the start on Tuesday, and going up against his former team, he should be able to put his team in a solid position to win. The Giants have won 6 of Ray’s last 7 starts, and Arizona’s lineup that struggled to score runs on a consistent basis since the trade deadline. Ray hasn’t been great in his last 2 home outings, but this could be a perfect opponent to get back on track against.

Arizona’s Zac Gallen enters this contest with a career-high 4.77 ERA on the season. It’s been an up-and-down season for Gallen, and while he’s been better in recent outings, has still struggled to find success on a consistent basis in 2025. He will face a Giants team that is rolling right now, having won 12 of their last 15 contests dating back to August 23. San Francisco is back above the .500-mark, and with the way they are playing right now, consider backing the Giants at home.

Diamondbacks vs Giants prediction: Giants ML (-140) available at time of publishing. Playable to -145.