Arizona Diamondbacks vs St. Louis Cardinals Prediction, Odds and Picks for Saturday, 05/24/25

The Diamondbacks and Cardinals are set for an afternoon matchup at Busch Stadium on Saturday. After the under cashed in Friday’s matchup, Saturday’s contest could be a bit more higher-scoring. Arizona’s Merrill Kelly has not been as effective on the road as he has been at home. Kelly’s ERA jumps from 2.35 at home to 4.28 on the road. In addition, his BAA goes from .156 to .248. The Cardinals are swinging the bats well in May, as they own a strong .268 batting average and .736 OPS this month. Kelly allowed just 1 hit over 7.0 scoreless innings in his last outing, but that was against a Colorado offense that is arguably the worst in baseball. St. Louis’ veteran lineup should be able to make life a little more difficult for him.

The Arizona offense has been strong all season long, and they enter this matchup ranking 4th in the league with a .780 OPS. Matthew Liberatore has allowed just 2 home runs through 52.1 innings on the season, but Arizona has blasted 72 home runs this season, which is good for fifth-most in the league. Look for the D-Backs to be ready to mash. Consider the over.

Diamondbacks vs Cardinals prediction: Over 8 (-110) available at time of publishing. Playable to -115.

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