Baltimore Orioles vs Chicago White Sox Prediction, Odds and Picks for Today, 09/15/25

In this game, we will see the Baltimore Orioles take on the Chicago White Sox. Both teams are riding 3-game losing streaks. One will break it today. On the mound, we have Kyle Bradish of the Orioles and Sean Burke of the White Sox. Bradish has only made 3 starts this year but has pitched well. He has pitched 17 innings, giving up 12 hits and 5 earned runs. The most positive aspect of his statistics is that he has not given up more than 4 hits in any of those starts. This statistic has a high chance of continuing as the White Sox are batting .194 over the past 6 games. The White Sox also rank 26^th in runs scored and 27^th in total hits this season. The hitting struggles of the White Sox are a major contributor to their 57-93 record. Bradish on the mound is not what the slumping White Sox were hoping for.

For the White Sox, Burke will take the mound. Burke has been struggling recently, highlighted by him getting pulled before the end of the 5th inning in 5 of his last 6 starts. With these early pulls, he has given up 20 hits and 10 runs in his last 16.1 innings. The main issue in his runs given up is that he has walked 2 or more batters in 6 of his last 8 starts. These pitching struggles are just what the Orioles lineup needs, considering they are batting .195 over the last 6 games. With both teams struggling to hit the ball, this game relies heavily on the pitching. With how shaky Burke has been, I am rolling with the Orioles to get the win.

Orioles vs White Sox prediction: Orioles ML (-155) available at time of publishing. Playable at that number.

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