Baltimore Orioles vs Chicago White Sox Prediction, Odds and Picks for Today, 09/16/25

The Baltimore Orioles turn to Dean Kremer, who has been serviceable this season with a 9-10 record, 4.43 ERA, and 132 strikeouts across 158.1 innings. While his overall numbers are middling, Kremer has shown stretches of effectiveness when he commands his fastball and keeps hitters off balance with his secondary pitches. His underlying metrics suggest he’s been slightly better than his ERA indicates, holding opponents to a hard hit rate around 37% and limiting barrels under 9%. Against a lineup like the White Sox that has struggled with consistency and power production, Kremer’s ability to limit damage and avoid big innings could put Baltimore in a strong position to control the tempo of the game.

The White Sox counter with Shane Smith, a rookie who has impressed in stretches, posting a 6-7 record with a 3.78 ERA, 1.18 WHIP, and 122 strikeouts. Smith has shown solid strikeout stuff and decent command, but he’s had issues allowing early baserunners, which can create pressure against stronger lineups. Baltimore’s offense, built on contact and timely power, has the tools to capitalize if Smith struggles to settle in quickly. While Smith’s long term outlook is promising, Kremer’s experience and steadier track record give the Orioles the edge in this matchup. With their lineup capable of manufacturing runs and Kremer positioned to limit Chicago’s scoring chances, the value lies on the road team.

Orioles vs White Sox Prediction: Orioles ML (-105) available at time of publishing. Playable to -120

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