Baltimore Orioles vs San Diego Padres Prediction, Odds and Picks for Tuesday, 09/02/25

The Baltimore Orioles turn to Tyler Wells on Tuesday, and he’s making his first big league start since April 2024 following elbow surgery. Wells worked through a careful rehab and is expected to be on a pitch limit, likely around 70 pitches, which could cap him at four innings. While his fastball and changeup looked sharp in minor league action, the step up against a major league lineup is a much bigger test, especially a lineup to the caliber of San Diego’s. His command will be under the microscope in his return. Baltimore’s offense has shown flashes, particularly with power in the middle of the order, but run production has been inconsistent. If the bats don’t provide early support, the combination of a limited starter and early pressure could leave them vulnerable before the bullpen takes over.

On the other side, the San Diego Padres hand the ball to veteran Yu Darvish, who has had an up and down 2025 but remains a pitcher capable of shutting down opponents when he’s locked in. Darvish gave up four runs in his last start, but before that had allowed one or fewer in three of his prior five outings, showing his ability to rebound quickly. His mix of breaking pitches and command should play well against an Orioles lineup still looking to find rhythm against quality right handers. Given Wells’ long layoff and expected limitations, the matchup leans in San Diego’s favor early, where Darvish has the edge in both experience and stamina. With that in mind, the best angle is backing the Padres in the first five innings, banking on Darvish to establish control before Baltimore’s bullpen can make it a battle.

Orioles vs Padres Prediction: Padres F5 ML (-155) available at time of publishing. Playable to -165.

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