Boston Red Sox vs Arizona Diamondbacks Prediction, Odds and Picks for Saturday, 09/06/25

The Boston Red Sox will look to bounce back tonight against the Arizona Diamondbacks after dropping last night’s game 10-5. Boston has now lost two straight and needs this series with only a 4.5-game cushion in the AL Wild Card. Taking the mound for Boston will be Lucas Giolito who enters with a 10-2 record and a 3.38 ERA. 

The Diamondbacks will counter with Brandon Pfaadt who enters with a 12-8 record and 5.33 ERA. Pfaadt has had a rough season, and I don’t expect things to get much easier for him tonight. In his last five starts, he’s 1-1 with a 6.84 ERA. We know this Diamondbacks team is more than capable of producing runs this season, and in their last 10 games they’re averaging 5.2 runs per game compared to Boston’s 4.3. However, I like Giolito in tonight’s matchup and he should be able to minimize the damage done by Arizona. Look for Boston to pick up a much needed win, making them my best bet of the night. 

Red Sox vs Diamondbacks prediction: Red Sox ML (-120) available at time of publishing. Playable at that number.