Boston Red Sox vs Houston Astros Prediction, Odds and Picks for Today, 04/01/26

After struggling offensively in their first two games of the season, the Houston Astros have started to find their groove, winning four straight games while averaging 9.3 runs per game over that span. As for the Red Sox, this is far from the start they envisioned, sitting at 1-4 on the season while averaging just 2.6 runs per game. Houston will look to complete the sweep as they send Michael Burrows to the mound who enters at 0-1 with a 7.94 ERA. For the Red Sox, Garrett Crochet gets the nod, coming in at 1-0 with a 0.00 ERA. 

Crochet will need to be careful with a couple of key bats in this Astros lineup – Yordan Alvarez is hitting .381 with three home runs and six RBIs, while Jose Altuve is batting .368 with two home runs and three RBIs. Both bullpens have had their issues early on, with Boston posting a 4.74 ERA and Houston not far behind at 4.24. While it’s still early in the season, the Astros are hitting .325 against lefties this season. Crochet has also struggled in his career against the Astros, going 0-3 with a 6.28 ERA in four starts. While Boston has the pitching advantage heading into this matchup with Crochet, this is going to be a tough spot for him as he tries to cool off a red-hot Astros offense. While Burrows didn’t look good in his first start of the season, I think he’ll settle down here against a Red Sox team that’s hitting just .208 on the season. Look for Houston to complete the sweep, making Astro my best bet of the day. 

Red Sox vs Astros prediction: Astros ML  (+130) available at time of publishing. Playable at that number.