Boston Red Sox vs Philadelphia Phillies Prediction, Odds and Picks for Today, 07/22/25

After ending the first half of the season with an impressive 10-game winning streak, the Red Sox have dropped 3 of their first 4 games after the break. The offense has gone quiet, as Boston has scored just 3 total runs in those 3 losses. Things won’t get any easier for them as the Sox go up against Philadelphia’s Cristopher Sanchez tonight. Sanchez was arguably the biggest all-star snub, and enters this matchup with a strong 2.50 ERA and 1.14 WHIP through 19 starts and 115.0 innings so far this season. Opponents are hitting just .219 against him when he pitches at Citizens Bank Park, and he is pitching on 9 days rest. Look for Sanchez to be effective on the mound.

Richard Fitts will be making his ninth start of the season for Boston. The Red Sox lost his first 6 outings before finding the win column in the last 2. However, those wins came against the Reds and Rockies at home, and now he has to face a strong Phillies lineup on the road. This will be Boston’s fifth straight road game to open the second half, and this club has struggled away from Fenway — owning a 22-28 record away from Boston. I’m backing the Phillies on the run line.

Red Sox vs Phillies prediction: Philadelphia -1.5 (+105) available at time of publishing. Playable to +100.

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