Boston Red Sox vs San Francisco Giants Prediction, Odds and Picks for Saturday, 06/21/25

The Red Sox won the first game of this series 7-5 on Friday night. Rafael Devers went hitless in the game, and he will undoubtedly be looking to do some damage in today’s contest against his former squad. The Red Sox are playing good baseball and building some momentum, but the trading Devers away leaves a big role to replace in their lineup. Devers was their best hitter, and even though they plated 7 runs last night, it may be a bit surprising to see the Red Sox reach that total again in this one. For reference, Boston had scored just 5 total runs in the first 3 games since trading Devers to the Giants.

The Red Sox have dropped 5 of Brayan Bello’s last 7 starts, and he has had the courtesy of making his last 3 starts at home. This is will be just his fourth road start of the season, and his first since May 28 against the Brewers. The Giants are a strong 23-14 at home, while the Red Sox are under the .500 mark with a record of 18-20 on the road. Look for Devers and company to find the win column in this one.

Red Sox vs Giants prediction: San Francisco ML (-135) available at time of publishing. Playable at that number.

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