Boston Red Sox vs St. Louis Cardinals Prediction, Odds and Picks for Today, 04/11/26

The Boston Red Sox and St. Louis Cardinals play on Saturday night, one of the FOX games of the week. The Cardinals held on for a 3-2 win on Friday night to open the series, mostly led by strong pitching from Dustin May and the bullpen. The Red Sox continue to struggle to open the season, now sitting at 4-9. On Saturday, we have good weather and a soft pitching matchup, and that looks like good hitting conditions to me. I am taking the over in this one.

Ranger Suarez and Kyle Leahy will toe the rubber to open the game. Suarez has struggled out of the gates in 2026, allowing 4 runs in each of his 2 starts, and failing to finish 5 innings in either turn. While that happens sometimes to open the season, there are some alarming metrics at work here too, and he is not one to trust right now. As for Leahy, he is a converted bullpen arm trying to make it in the rotation. He has been adequate to the task, but certainly not good. The Cardinals have been scoring well on offense, and the Sox desperately need their bats to wake up. I think we see this game push over the total.

Red Sox vs Cardinals Prediction: Over 8 (-110) available at the time of publishing. Playable to 8.5.

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