Boston Red Sox vs St. Louis Cardinals Prediction, Odds and Picks for Today, 04/12/26

The Boston Red Sox and St. Louis Cardinals will meet in a rubber match on Sunday after Boston’s late-game explosion on Saturday, scoring 5 runs in the 9th to pull away for a 7-1 win. On the mound, Boston turns to Brayan Bello, who has struggled early in the season. Through his 2 starts, he’s 0-1 with a 9.00 ERA, allowing 13 hits and 8 runs over just 8 innings. For the Cardinals, they’ll send Andre Pallante to the mound, who is 1-0 with a 1.80 ERA. Pallante isn’t a strikeout pitcher, but he’s effective as he is able to generate weak contact and get ground balls.

Offensively, these teams are fairly even. Boston is hitting .226 on the season and averaging 3.8 runs per game, while St. Louis is batting .224 and averaging 4.5 runs per game. The Cardinals may have the advantage with Pallante on the mound, but we just saw what their bullpen is capable of doing late in the game. The Cardinals bullpen holds a 5.37 ERA compared to Boston’s 3.76, something they need to tighten up as the season goes on. Taking everything into consideration, I think the Cardinals can get to Bello early on, and Pallante will likely go 5 or 6 innings, handing the ball over to the bullpen for the remainder of the game. Despite the bullpens struggles, I think they settle down in this spot and hold onto an early lead. Look for the Cardinals to get the job done and secure a much needed series win. 

Red Sox vs Cardinals prediction: St. Louis Cardinals ML (+105) available at time of publishing. Playable at that number.

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