Boston Red Sox vs Toronto Blue Jays Prediction, Odds and Picks for Today, 05/01/25

The Red Sox and Blue Jays meet again Thursday night in the second set of a key early-season series between AL East rivals. Boston enters the game looking to shake off a gut-wrenching loss from last night — a 6-0 lead squandered in extra innings despite a solid season debut from Lucas Giolito. The bullpen’s collapse was uncharacteristic, especially with some of their more reliable arms on the mound, but it underscores the inconsistency that has hurt the Red Sox in 2025. Now sitting at 17-15, Boston will try to rebound behind Tanner Houck, who despite a rough 7.58 ERA, has historically dominated Toronto’s lineup. In 114 combined at-bats, the Blue Jays are hitting just .202 against him, suggesting a potential bounce-back performance is on deck.

Toronto, meanwhile, is trending downward after a decent start to the year, dropping to 2 games under .500. Still, they’ve had Boston’s number so far, winning 4 of the 6 matchups between the teams. The Jays will send Jose Berrios to the hill, but his 5.94 ERA at Rogers Centre this season raises questions about his effectiveness, especially against a Red Sox lineup that’s shown the ability to score in bunches. This pick-em line also doesn’t make sense to me given Houck’s struggles and Toronto’s home-field advantage. With the Jays having a taxed bullpen after an extra-inning game last night, look for Boston’s bats to capitalize later, even if Berrios has a solid outing.

Red Sox vs Blue Jays prediction: Red Sox ML (-110) available at time of publishing. Playable to -125.

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