Chicago Cubs vs Milwaukee Brewers Prediction, Odds and Picks for Today, 10/04/25

In this game, we will see Game 1 of the Nationals League Division Series between the Chicago Cubs and the Milwaukee Brewers. These are 2 teams very familiar with one another with the Cubs winning their regular season series 7-6. On the mound today, we have Matthew Boyd of the Cubs and Freddy Peralta of the Brewers. Boyd pitched great on the year with a 3.21 ERA and a 14-8 record. Even with these numbers, Boyd has given up 3+ runs in 5 of his last 6 away starts. In his games against the Brewers this season he has pitched 10.1 innings giving up 12 hits and 9 earned runs. His struggles against the Brewers show the dominance of the Brewers bats this season. On the year, the Brewers rank 3^rd in batting average, hits, and runs scored. The Brewers also hold a 52-29 home record, meaning it could be a tough game for the Cubs.

For the Brewers, Peralta will take the mound. Peralta has been great for the Brewers all season with a 2.70 ERA and a 17-6 record. His numbers are even better at home where he has a 1.77 ERA giving up 18 earned runs in 91.2 total innings pitched. Peralta has faced the Cubs 4 times this season where he has pitched 21 innings and given up 12 hits and 8 earned runs. While the Cubs have hit well all season, in the first 2 games against the San Diego Padres in the previous series they only got a total of 10 hits. Hitting like this tends to struggle against the Brewers as their bullpen has improved as the season has gone on. Overall, Peralta is poised to make a great start in this one and I trust the Brewers bats significantly more than the Cubs. Give me the Brewers to get the win.

Cubs vs. Brewers Prediction: Brewers ML (-160) available at the time of publishing. Playable at that number.