Chicago Cubs vs Pittsburgh Pirates Prediction, Odds and Picks for Today, 09/17/25
Cubs vs Pirates Pickswise Expert Predictions
The Chicago Cubs will go for the sweep on Wednesday as they look to wrap up their three-game series against the Pittsburgh Pirates. Taking the mound for the Cubs will be the left-hander, Matthew Boyd, who enters with a 13-8 record and a 3.05 ERA. Boyd has struggled recently, going 2-2 with a 5.97 ERA in his last five starts.
For the Pirates, Johan Oviedo will get the start, entering with a 2-0 record and a 2.81 ERA. Oviedo has pitched well and may be able to limit the number of runs scored by the Cubs, but the Pirates are averaging just 2.2 runs per game over their last 10. The Cubs offense has been slightly better, averaging 3.6 runs per game. Pittsburgh has also been among the league’s worst against left-handed pitching, batting just .218 – which puts them 29th in the majors. The Cubs have been the better team all season and I don’t think they’ll have any issues in this matchup against the Pirates.
Cubs vs Pirates prediction: Cubs ML (-155) available at time of publishing. Playable at that number.
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Jason Fragomeni
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