Chicago Cubs vs San Francisco Giants Prediction, Odds and Picks for Today, 08/26/25

The Cubs hand the ball to veteran left hander Matthew Boyd, who has quietly been one of the most effective starters in the National League this season. Boyd enters with a strong 12–6 record, 2.61 ERA, and 1.04 WHIP, while consistently limiting hard contact with an average exit velocity against of just 88.2 mph. His ability to control innings was on full display in his recent outing against the Yankees, where he fired eight scoreless frames, scattering 4 hits with no walks and striking out 6. With Chicago’s defense supporting his ground ball tendencies and a lineup capable of manufacturing early runs, the Cubs are in a strong position to strike first. Their offense has been steady of late, with a balanced mix of power and contact hitters giving Boyd the support he needs to work confidently in the early innings.

The Giants counter with Justin Verlander, the future Hall of Famer who has endured a difficult season. Through 22 starts, he owns a 1–10 record and 4.64 ERA, numbers that reflect his inconsistency and decline from peak form. While Verlander has flashed vintage moments and recently surpassed 3,500 career strikeouts, too often he has struggled with command and elevated pitch counts, preventing him from working deep into games. That puts added pressure on a Giants lineup that has been inconsistent and often slow to produce runs against quality pitching. With Boyd in strong form and Verlander struggling to regain rhythm, the advantage early tilts toward Chicago.

Cubs vs Giants Prediction: Cubs F5 ML (-135) available at time of publishing. Playable to -145

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