Chicago Cubs vs St. Louis Cardinals Prediction, Odds and Picks for Monday, 06/23/25

A rivalry matchup is in store for Monday night as the Cardinals host the Cubs at Busch Stadium. It’s the first meeting of the season for the NL Central rivals. The Cubs have dropped 3 of their last 4 games, but it’s not been for a lack of offense. Chicago has scored 27 runs over its last 4 games, and only the Dodgers have scored more total runs on the season than the Cubs. St. Louis will send Matthew Liberatore to the mound, and he could have his hands full. The Cubs hit lefties well, and their offense is in a groove right now.

On the other side, the St. Louis offense is starting to turn a corner. The Cardinals have won 6 of their last 8 games thanks to scoring over 6 runs per game in that stretch. They are a much better team offensively when playing at home, as their team OPS goes from .691 on the road to .746 at Busch Stadium. They will go up against Chicago starter Ben Brown, who owns a less-than-stellar 5.57 ERA and 1.48 WHIP through 74.1 innings this season. Both of these offenses are rolling right now, and neither starting pitcher has seen overwhelming success so far this season. Roll with the Over in this one.

Cubs vs Cardinals prediction: Over 9 (-105) available at time of publishing. Playable to -110.

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