Chicago Cubs vs St. Louis Cardinals Prediction, Odds and Picks for Today, 08/08/25

The Chicago Cubs face the St. Louis Cardinals on Friday. On the mound are Matthew Boyd of the Cubs and Michael McGreevy of the Cardinals. Boyd has looked incredible in 4 of his last 5 starts. In those 4 he has pitched 27.0 innings while giving up just 15 hits and no earned runs. In the other start he gave up 5 runs in 5.0 innings against the Milwaukee Brewers. That game was the only time in his last 13 starts that he allowed more than 2 earned runs. Additionally, he has faced the Cardinals twice this year and has pitched 11.0 innings, giving up 6 hits and no earned runs. For the Cardinals’ lineup, they are currently batting .143 against Boyd through 56 at-bats. Based on these numbers, I have a feeling that Boyd may be in for another good start.

For the Cardinals, McGreevy will take the mound. He has given up 17 runs in his last 22.0 innings. McGreevy also struggled against the Cubs earlier this year, giving up 5 runs in just 4.2 innings. Also working against the Cardinals is that the Cubs rank third in batting average and second in runs scored in away games this year. Making matters worse, the Cardinals’ bullpen has given up 14 runs over the past 5 games. This means that St. Louis is looking shaky in the pitching department for a full 9 innings. I am rolling with Chicago to get the win in this one.

Cubs vs Cardinals prediction: Cubs ML (-150) available at time of publishing. Playable at that number.

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